PhD Position on enriching digital twins of the human heart with real ion channels

Join us to develop hybrid bio-digital heart cell models, study gene variants and drug effects, and help create faster, more accurate methods to predict dangerous heart mutations.

PhD Position on enriching digital twins of the human heart with real ion channels

Dit ga je doen

Each beat of our hearts is coordinated by electrical impulses generated by the heart tissue itself. These electrical impulses are generated in the muscle cells through the action of ion channels in the cell membrane, allowing entry and exit of charged ions.

Variations in the genes encoding ion channels can cause disruption of the electrical impulses, and can cause a lethal stop of the heart beat. Prediction whether a newly found gene variation is dangerous or not is difficult and requires a lot of experimental work. In this project we will continue development of a new high-throughput method that will speed up and improve such predictions.

We will further develop a combination of automated patch clamping and dynamic clamping. Using these techniques, we can create hybrid biological-digital twins of heart cells that are suitable for studying the effects of the ion channel variants, and will be used to test drug effects. Important advantage of this approach is that we merge the actual biological ion channels into a simulation of the electrical impulses of heart cells, thereby capturing the real biology and real ion channel-drug interactions. Within this project we will develop the implementation of this technique and work towards use in clinical diagnostics.

Key objectives include:

• Optimising expression of ion channel variants in cell lines.
• Performing automated patch clamping experiments.
• Validation of hybrid biological-digital twin methods and experiments.
• Development of protocols for integration of the method in clinical diagnostics.

Hier ga je werken

The Netherlands Heart Foundation funds this project through its public-private partnership programme, and additional contributions are made by Nanion Technologies GmBH (Munich, Germany) and Elements Srl (Cesena, Italy). The project is coordinated by Dr. Teun de Boer. The PhD candidate will work at the Department of Medical Physiology of the UMC Utrecht and will have access to state of the art technology. The candidate will work in a stimulating and interdisciplinary research team, and will collaborate with a post-doc employed on the same project.

Dit neem je mee

We are seeking a highly motivated researcher with a MSc degree and a strong collaborative mindset that can thrive in an international translational research environment. The candidate must be proficient in spoken and written English, and have a solid background in biomedical engineering. Experience with (electro)physiology and/or mathematical modeling are considered advantageous.

t.p.deboer@umcutrecht.nl

a.a.b.vanveen@umcutrecht.nl

Dit bieden we jou

• Year-end bonus of 8.3% and holiday allowance of 8%.
• Pension insurance with ABP. We take care of approximately 70% of the monthly contribution.
• 100% public transport reimbursement. Are you coming on foot, by bike or by car? You will then receive a reimbursement of € 0.18 per km (by car up to a max. of 40 km one way).
• Possibilities to develop yourself personally and professionally.
• The option to select additional employment benefits in exchange for gross salary, such as purchasing a bicycle and memberships.