Postdoc Exp. Hematology: Exploring the macrophage landscape in AML

Postdoc Exp. Hematology: Exploring the macrophage landscape in AML

Closing date: June 1

Job description

The general aims of the division of Experimental Hematology are to obtain detailed knowledge on (molecular) mechanisms that determine hematopoietic stem cell self-renewal and differentiation, with the ultimate goal to deepen our insights in the development of human leukemias. We have a specific interest in dissecting the clonal heterogeneity of leukemias and recently developed tools that allow us to identify and prospectively isolate genetically distinct clones within individual patients. Also, we have a strong interest in uncovering the immune microenvironment in AML. Within the latter project, we are currently looking for a motivated post-doc that will further investigate the role of macrophages in AML. This project was recently awarded by the Dutch cancer Foundation and builds further on our finding that M2 tumor-supportive macrophages are highly relevant for tumor progression (see PMID: 37058562; 37646656. Via a process termed “macrophage cuddling” we have shown that that direct macrophage-leukemic blasts interactions are highly relevant for leukemia development, and the underlying molecular and cell biological mechanisms will be investigated in the current project.

Where you will work

The University Medical Center Groningen (UMCG) is one of the largest academic hospitals in the Netherlands and the largest employer in the Northern Netherlands. In addition to providing clinical care, it is a constituent member of the University of Groningen with much focus on core research, training, and education. The Department of Experimental Hematology is directly embedded within the clinical Hematology department, and allows for direct clinical translation of the latest insights from our fundamental research lines.

For an overview of our work please see: https://pubmed.ncbi.nlm.nih.gov/?term=schuringa+jj
For further information please contact: prof.dr. J.J.Schuringa ([email protected])

What do we need

• You have a PhD in a biomedical/life sciences-related subject.
• You have experience in cell biological techniques (e.g. eukaryotic tissue culture).
• You have affinity with molecular biology techniques.
• You have excellent writing and speaking/presentation skills in English.
• You are enthusiastic, ambitious and are a team player.

What do we offer

The Postdoc position is 24 months after appointment. Expected starting date at the latest September 1st, 2025. Based on a full-time appointment, at the level of Postdoc, the salary will be a maximum of € 5.504,- gross per month (scale 10). The exact salary will depend on the applicant’s qualifications and relevant experience. Additionally, the UMCG offers an 8% holiday allowance, an 8.3% year-end bonus. The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).