PhD in Synthesis and Modification of Novel Peptide-Based Amphiphiles

Job description

Peptides, beyond their essential role in biology and life processes, are also of significant importance in academic research and industry as bio-based, biodegradable components with diverse applications, including biomaterials, cosmetics, and pharmaceuticals. Their function in these environments is largely determined by supramolecular interactions, which are complex and challenging to predict, particularly in multicomponent systems. This collaborative project between few Dutch Universities and an Industrial Partner aims to address this challenge by developing advanced tools to understand and predict the properties of peptide-based materials.

The focus of this project is the synthesis and functionalization of peptide-based amphiphiles to establish a versatile materials platform for applications ranging from bio-based detergents to advanced biomaterials. Leveraging automated parallel peptide synthesis and purification systems, we will create libraries of short peptides and their derivatives. Special attention will be given to exploring N-mono- and N-bis-functionalized amino acids and other modifications using cutting-edge catalytic coupling methods. Additionally, the stereochemical aspects and biodegradability of the resulting compounds will be investigated.

Collaboration will be a key of this project, with opportunities to engage in joint experimental work within a dynamic research environment. By synthesizing and characterizing these materials, this research seeks to advance both fundamental understanding and practical applications in peptide-based systems.

Organization

The University of Groningen is a research university, currently in or around the top 100 on several influential ranking lists. The Faculty of Science and Engineering (FSE) is the largest faculty within the University, offering first-rate education and research in a wide range of science and engineering disciplines.

The mission of the Stratingh Institute for Chemistry is to perform excellent research and teaching in molecular and supramolecular chemistry. Core activities in the chemical sciences such as bioorganic chemistry, organic chemistry, molecular inorganic chemistry and molecular materials chemistry are embedded in the institute. The research programme is focused on synthesis, catalysis, functional materials, bio-organic chemistry/chemical biology and systems chemistry/complex molecular systems.

The research program of the Feringa group is focused on synthetic and physical organic chemistry. Inspired by Nature's principles of molecular assembly, recognition, transport, motion and catalysis, the goal is to exploit the full potential of synthetic chemistry to create new structures and functions. A major part of the research is directed towards dynamic molecular systems. The focus is on molecular nanoscience, novel responsive materials and photo-pharma exploring biohybrid systems, self-assembly, molecular switches and motors. A second part of the program deals with the development (and application in chemical biology) of novel stereoselective synthesis methods and asymmetric catalysis. Chirality is a leading theme and over the years a unique and broad expertise in fundamental aspects of stereochemistry has been acquired including chiroptical phenomena, chiral amplification and origin of chirality.

Qualifications

We are looking for candidates who meet the following requirements:

• A Master’s degree in chemistry or a related field.
• Knowledge and experience in synthetic organic chemistry; experience in peptide chemistry or supramolecular chemistry is an advantage.
• The ability to work independently and proactively, with strong problem-solving skills and self-motivation.
• A relevant academic record, including publications in peer-reviewed journals, is a plus.

Experience in peptide synthesis, stereochemistry, or catalysis will be considered an asset.

Applicants whose first language is not English must provide evidence of proficiency, as outlined by the University of Groningen’s English Language Requirements.

Organisation

Conditions of employment

We offer you in accordance with the Collective Labour Agreement for Dutch Universities:

• A salary of € 2,901 gross per month in the first year, up to a maximum of € 3,707 gross per month in the fourth and final year, based on a full-time position (1.0 FTE).
• A holiday allowance of 8% gross annual income.
• An 8.3% year-end bonus.
• A position for four years; you will get a temporary position of one year with the option of renewal for another three years; prolongation of the contract is contingent on sufficient progress in the first year to indicate that a successful completion of the PhD thesis within the next three years is to be expected.
• A university PhD training programme is part of the agreement and the successful candidates will be enrolled in the Graduate School of Science and Engineering.

The starting date is flexible.