PhD on Treatment of Veterinary Patients with Liposomal Formulations

The treatment of leishmaniosis can cause toxicity. Encapsulating drugs in liposomes allows targeted delivery, reducing toxicity. This project aims to establish protocols and coordinate efforts to offer liposomal treatments to dogs with leishmaniosis. Liposomes with various lipid compositions and anti-leishmania drugs will be prepared and tested for quality and stability. Effective liposomes will be tested on infected canine macrophages for toxicity, efficacy, and uptake. The best formulation will be GMP-prepared, undergo quality control, and be tested for clinical efficacy in patients.

Wat ga je doen?

You will collaborate closely with veterinary clinicians and clinical pharmacists to develop protocols for the Good Manufacturing Practice (GMP) preparation of liposomal formulations. You take a lead role in the preparation and testing of liposomes with anti-leishmania drugs, focusing on quality control, stability, and efficacy.

You'll coordinate the project to offer liposomal treatments to veterinary patients, ensuring reproducibility and sterility of the final product. And evaluate the efficacy of liposomal formulations through clinical observation and parameter monitoring in veterinary patients.

Wat breng je mee?

• You put your collaboration and communication skills to good use. This means, for example, that you easily seek collaboration with other departments. You are keen on personal and professional development for yourself and people you work with.
• You have proficiency in English language.
• You have an MSc degree in pharmaceutical sciences, (biomedical) engineering, or related field (candidates nearing completion of their MSc are welcome to apply).
• Prior experience with any of the following topics is beneficial but not required: (mammalian) cell culture, nanoparticle preparation, microfluidics, nanoparticle characterisation, flow cytometry, fluorescence microscopy

Wat bieden wij?

• a position for one year, which will be extended by three years upon satisfactory performance;
• a working week of 36 to 40 hours and a gross monthly salary between € 2.770,- and € 3.539,- in the case of full-time employment (salary scale P under the Collective Labour Agreement for Dutch Universities (CAO NU);
• 8% holiday pay and 8.3% year-end bonus;
• a pension scheme, partially paid parental leave and flexible terms of employment based on the CAO NU.