Postdoc Position Biomedical Sciences

This junior postdoc position in Biomedical Sciences focuses on multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system marked by inflammation and neurodegeneration. Current immunomodulatory therapies decrease relapse activity, yet the risk of developing progressive MS is not mitigated. Tailored clinical trials aimed at preserving axons by promoting remyelination have thus far failed to provide effective therapeutic interventions for progressive MS.

Job description

Our recent findings point to localized neurogenesis in a subset of MS lesions by an OPC-to-neuron conversion in response to microenvironmental changes. This project aims to identify signals triggering neurogenesis within MS lesions.

You will leverage single-nucleus RNAseq data and generate spatial imaging and transcriptomic profiles at subcellular resolution of MS lesions, to delineate the transition states of OPC-to-neuron transformation and decipher the involved receptor-ligand interaction(s). In addition, the project entails replicating the neurogenic process using MS-iPSC-derived OPCs and investigating how the lesions relate to neuropathological and clinical disease parameters.

The position is funded by Stichting MS Research.

Working environment

The research at the Department of Biomedical Sciences (BMS) at the UMC Groningen focusses on understanding basic functions and processes of the cells, tissues and organs and how they lead to diseases if disturbed. The dept BMS strives to identify potential mechanisms and targets to prevent or cure disease, and to promote more healthy years. The position is also embedded in the MS Center Noord Nederland.

Wat vragen wij

A junior Postdoc with a PhD degree in molecular cell biology or a related field. We are looking for an enthusiastic, highly motivated and talented postdoctoral researcher with affinity for neuroscience and a strong scientific drive.

• Expertise with bioinformatic analysis and cell culture; experience including human iPSCs is an advantage.
• A flexible working attitude, team player mentality, good oral and written communication skills in English, and a result-driven and pro-active attitude.

What do we offer

A junior postdoc position for a temporary contract of 12 months, preferably starting April, 2026, with the possibility of extension for 18 months. The starting salary is dependent on your qualifications and relevant experience in scale 10 (max. €5.669 gross salary based on a full-time position). Additionally, the UMCG offers an 8% holiday allowance and an 8.3% year-end bonus. The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).