PhD Candidate in Immuno-biology and Infectious disease

PhD Candidate in Immuno-biology and Infectious disease

The Faculty of Science Leiden, the Leiden Institute of Biology and Leiden Institute of Chemistry are looking for a PhD candidate to pursue research on the development of host-directed therapeutics for mycobacterial infections.

Mycobacterial infections are among the top 10 cause of death globally. Although cases of tuberculosis (Mtb) are typically decreasing because of concerted global efforts, respiratory infections caused by non-tuberculous mycobacteria (NTM), such as M. avium, have more than doubled since the year 2000. The increase in antibiotic resistance is a major concern for both Mtb and NTM, and there is need for novel therapeutics. This PhD project investigates the potential of targeting host-cell metabolism to deprive intracellular bacteria of essential nutrients and boost the immune response. The candidate will work as part of an interdisciplinary team to help characterize how pathogenic mycobacteria rewire host-cell metabolism and identify novel drug targets. They will be trained in a variety of powerful, modern analytic techniques including metabolomics, transcriptomics, and proteomics and work on advanced biological systems for modelling infection including macrophages, organoids, zebrafish, primary and clinical samples.

Embedding within the Institutes of Biology and Chemistry at Leiden will enable the candidate to maximize their learning opportunities, participate in local research networks, and access leading research facilities.

Candidate profile:

Applications are invited from outstanding graduates who meet the following criteria:

• BSc, including mathematics, cell and molecular biology
• Honors (first class) or MSc degree in Microbiology/Immunology/Pharmaceutical Science, or related degree
• Accreditation in Laboratory Animal Science (DEC article 9) is highly desirable, but not essential
• Lab experience including:
  • mammalian cell culture, cell biology, and infection biology [essential]
  • molecular biology, assay development
  • lipidomics/metabolomics/transcriptomics [desirable]
• Analytical thinking, data analysis, and critical problem-solving skills.
• Commitment to rigorous scientific standards and accurate record keeping
• Time management and ability to work independently
• Excellent command of written and spoken English (demonstrated through prior publications, theses, presentations)
• Strong teamwork mentality

Key responsibilities:

• Independent research including planning experiments, analyzing and reporting data;
• Participate in lab meetings, departmental work discussions, and external conferences;
• Contribute to writing and publication of manuscripts and grants;
• Supervise BSc and MSc internship projects;
• Contribute to teaching in the department (laboratory classes);
• Complete training in transferrable and scientific skills as outlined in the Ph.D. degree criteria;
• Completion of PhD thesis within 4 years.

Description of organisation and terms of employment

The position is open and will commence as soon as a suitable candidate is admitted. We offer a position for 12 months and upon satisfactory performance to be extended for three more years. You will be appointed in accordance with the Collective Labour Agreement for Dutch Universities. The salary ranges from € 2.901,- to € 3.707,- gross per month (pay scale P in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3%), training and career development. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break.

Faculty

The Faculty of Science at Leiden University is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to make a contribution to addressing the major societal challenges of the future.

The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organized in eight institutes. These institutes offer eight bachelors’ and twelve master’s programmes. The faculty has grown strongly in recent years and now has more than 2,300 staff and over 5,000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together.

University

Leiden University is one of Europe’s leading international research universities.

Thanks to its committed and inspired employees, the university enjoys a leading role in academic research and education. Leiden also scores very well every year in prominent rankings. This means that, to maintain our position, the bar is set very high. Regardless of the work you do at our university, you are always encouraged to broaden your horizons, develop your talents and reach your full potential. Will you become our newest colleague?

If you have questions about your eligibility or other administrative questions, please contact Jessica van Krimpen (j.e.van.krimpen@lic.leidenuniv.nl).

Are you enthusiastic about this vacancy? We are looking forward to getting to know you. 😊