Postdoc Mechanobiology of Extracellular Matrix Materials

Postdoc mechanobiology of designer extracellular matrix materials with programmable cell-matrix interactions

Job description

Biomaterials are widely used as scaffolds for cell culture in regenerative medicine, organ-on-chip human disease models, and cell-based meat production. However, they are currently mostly based on structural proteins sourced from animal tissues. Animal-derived products are unsustainable and difficult to customize. The goal of this project is to develop recombinant protein-based biomaterials capable of guiding cell functions by emulating the extracellular matrix of tissues.

Your role in this project will be to design the mechanobiological properties of the tissue-mimicking biopolymer networks via programmable cell-matrix interactions. Biomaterials should ideally permit independent control of their physical and biochemical properties because cells sense and respond to both cues. This has proven challenging with natural proteins since increasing the stiffness via the protein concentration also changes the ligand density. To address this challenge, you will explore composite materials of recombinant collagen and elastin-like polypeptides (ELPs). ELPs have no intrinsic bioactivity and can thus be made selectively bioactive by incorporating selected peptide motifs. You will explore how to program the physical and biochemical properties of these materials to steer cell differentiation and cell functions with a focus on endothelial cells and fibroblasts, relevant for soft tissue repair, and on pluripotent stem cells, relevant for cell-based meat or cell therapies.

You will be part of a unique multidisciplinary team. The Daran lab at TU Delft is establishing a dedicated microbial cell factory to produce collagen and elastin while the Koenderink lab at TU Delft is using their expertise in cell and tissue biophysics and mechanobiology to design materials with tissue-mimicking biomechanical properties. In close collaboration with the companies DSM, Meatable and VIVOLTA, we will explore applications of these materials for soft tissue repair and cell-based meat. Your findings will provide fundamental insights in tissue biophysics and mechanobiology, and a strong basis for rational design of biomaterials for applications in soft tissue repair and cell-based meat.

Requirements

We seek an outstanding experimental biophysicist with a strong affinity for research at the interface of physics, mechanobiology and biomaterials science and with relevant research experience in fields such as biophysics, mechanobiology, bioengineering or soft matter physics. We are looking for a candidate with a high level of intellectual creativity, genuine interest in fundamental research, who enjoys being part of a collaborative international team and easily communicates with scientists from different disciplines.

Applicants must:

• hold a PhD, or approach its completion, in biophysics or a closely related discipline;
• have experience with biophysics and/or mechanobiology, optical imaging, mammalian cell culture and analysis skills;
• have excellent written and spoken English skills;
• thrive in an international, ambitious, multidisciplinary, and highly collaborative environment.

TU Delft (Delft University of Technology)

Delft University of Technology is built on strong foundations. As creators of the world-famous Dutch waterworks and pioneers in biotech, TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. For generations, our engineers have proven to be entrepreneurial problem-solvers, both in business and in a social context.

At TU Delft we embrace diversity as one of our core values and we actively engage to be a university where you feel at home and can flourish. We value different perspectives and qualities. We believe this makes our work more innovative, the TU Delft community more vibrant and the world more just. Together, we imagine, invent and create solutions using technology to have a positive impact on a global scale. That is why we invite you to apply. Your application will receive fair consideration.

Challenge. Change. Impact!

Faculty Applied Sciences

With more than 1,100 employees, including 150 pioneering principal investigators, as well as a population of about 3,600 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we educate innovative students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers.