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Cells are crowded with biomolecules, which could affect protein behavior through macromolecular crowding. Crowding depends on stress and cell type and, therefore, its consequences will vary. This makes it pertinent to determine intracellular crowding in different (disease) states and identify its potentially toxic consequences.
As PhD candidate in this project, you will aim to develop better tools to measure crowding and its consequences. We are experts in sensor development, providing you with an ideal springboard and environment. Your sensors will be used in collaborations, thus finding immediate application. To understand the observations in living cells, you will make artificial cells using microfluidics. Here, you can build on our previous work on making artificial cells with high crowding, but you can also use your own creativity. You will do a detailed analysis of your probes in artificial cells with fluorescence microscopy techniques such as FRET-FLIM to better understand how crowding and its consequences correlate.
This PhD position may be the right fit for you, if you recognize yourself in several or all of the following:
We offer:
We work on a better future. In order to do that, we join forces with academics, students, alumni, social partners, the government and the corporate world. Together, we look for sustainable solutions to the big challenges of today and tomorrow.
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