PhD Candidate in the Field of Supramolecular Biomaterials

The Faculty of Science Leiden and Leiden Institute of Chemistry, SBC department are looking for a

PhD candidate in the field of supramolecular biomaterials

Work and profile

The biochemical and biophysical cues of the stem cell environment that act in a concerted and spatiotemporal manner lead to the formation of the 200 cell types and organs of the human body; how this precisely occurs remains unclear, but it is necessary to guide their production for use in the biomedical area. Standard differentiation protocols in vitro mimic known stages in development by the timed addition of biochemical cues on 2D substrates, however these protocols lack the complexity of the 3D natural extracellular matrix (ECM), with its mechanical character that evolves in time. Supramolecular materials can recapitulate the structural and dynamic character of the ECM being based on non-covalent interactions, however their mechanically soft character remains challenging to mimic the properties of adult tissues. In this project, we will study supramolecular biomaterials whose properties can be mechanically modified in both space and time using external triggers. The candidate will focus on stem cell (3D) culture and differentiation, and directing cell behavior in advanced 3D in vitro models.

Selection criteria

• Master’s degree in life sciences or related field
• Experience with (3D) cell culture
• Excellent proficiency in English;
• Ability to work as a team player in a multidisciplinary environment;
• Initiative, creativity and an independent working attitude are highly valued

Description of organisation and terms of employment

We offer a position for 1 year initially, with a possibility of extension to a full PhD contract upon satisfactory performance. You will be appointed in accordance with the Collective Labour Agreement for Dutch Universities. The salary ranges from € 2.770,- to € 3.539,- gross per month (pay scale P).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. For international spouses we have set up a dual career programme. Candidates from outside the Netherlands may be eligible for a substantial tax break.

Faculty

The Faculty of Science at Leiden University is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to make a contribution to addressing the major societal challenges of the future.

The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organized in eight institutes. These institutes offer eight bachelors’ and twelve master’s programmes. The faculty has grown strongly in recent years and now has more than 2,300 staff and over 5,000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together.

University

Leiden University is one of Europe’s leading international research universities.

Thanks to its committed and inspired employees, the university enjoys a leading role in academic research and education. Leiden also scores very well every year in prominent rankings. This means that, to maintain our position, the bar is set very high. Regardless of the work you do at our university, you are always encouraged to broaden your horizons, develop your talents and reach your full potential. Will you