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PhD Immune function in chronic lymphocytic leukemia

Posted 6 May 2025
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Work experience
0 to 1 years
Full-time / part-time
Full-time
Job function
Salary
€3,017 - €3,824 per month
Degree level
Required language
English (Fluent)
Deadline
14 May 2025 00:00

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Working at Amsterdam UMC

PhD Immune function in chronic lymphocytic leukemia

We are looking for an enthusiastic PhD candidate to contribute to novel CLL research focused on immune dysfunction and therapy.

The project

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. While targeted therapies have improved outcomes, they are not curative and long-term use is associated with resistance, toxicity, and high costs.

T cell-based strategies, such as CAR-T cells, are promising, but show limited efficacy in CLL due to disease-associated T-cell dysfunction. In the Netherlands, we run multiple international trials testing targeted and T cell-based therapies, with centralized collection of molecular and immunophenotypic data and patient samples.

This project is part of a national initiative with three PhD positions focused on radiomics, MRD, and immune dysfunction, supported by the Dutch foundation for Hemato-Oncology (HOVON).

Would you like to know more about the different phases within the PhD trajectory? You can read more about this on this page.

About your role

In this PhD project, you will use high-dimensional datasets to understand treatment responses, predict which patients benefit from specific therapies, and help design future trials testing personalized approaches. You will perform wet-lab experiments (e.g. high-dimensional flow cytometry, molecular and genetic assays) and integrate these with computational analyses using biostatistics and bioinformatics.

About you

We are seeking a motivated and collaborative PhD candidate with a strong academic background and a (nearly completed) Master’s degree in molecular sciences, biomedical sciences, bioinformatics, or a related field.

Furthermore you should have:

  • A genuine interest in immunology and cellular biology;
  • Practical experience with cell culture and high-dimensional flow cytometry;
  • Affinity with biostatistics and/or bioinformatics is strongly preferred;
  • A proactive and creative mindset, with the ability to work both independently and in a team;
  • Strong communication skills, given the collaborative and multidisciplinary nature of the project.

Our offer

  • A flying start to your career in scientific research.
  • Plenty of room for your drive to shape tomorrow's healthcare.
  • Working on large-scale and in-house research, with motivated colleagues from all over the world.
  • You will be employed by Amsterdam UMC Research BV.
  • A contract for 12 months, with the intention to extend for a total of 4 years.
  • Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.
  • For >7 km each way, 100% reimbursement for public transport travel costs and, for private transport, €0.18 per km up to a maximum of 40 km each way.
  • Do you prefer walking or cycling? Take advantage of our good bike scheme. Moreover, you will receive a reimbursement of €0.18 per km.

About your workplace

You will be part of the Immuno-Hematology group embedded in the department of Hematology at Amsterdam UMC. This department is a highly collaborative environment with lots of knowledge on hematological malignancies and immune-dysfunction as well as clinical trials and translational research.

Amsterdam UMC Research BV supports non-profit scientific research. In doing so, we provide researchers with everything they need to excel. Our principal investigators (PIs) and project leaders offer support in the field of project management, finance and human resources. In medical scientific research projects, legal support is also provided.

Amsterdam UMC has an open culture. This means that we hope that everyone feels welcome in our organization and that we strive to offer equal opportunities to everyone. We therefore cordially invite all interested parties to respond to this vacancy.

Applications should be written in English and contain:

  • Cover letter explaining relevant work experience and your motivation for joining our team;
  • Curriculum Vitae;
  • Names and addresses of two references.

During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.

If you have any questions about this position, please feel free to contact Prof. Arnon Kater, clinical and translational hematologist, via a.p.kater@amsterdamumc.nl or Fleur Peters, postdoc molecular immunology via f.s.peters@amsterdamumc.nl.

For more information about the application procedure, please contact Chey Edwards, Recruitment advisor, via c.i.edwards@amsterdamumc.nl.

A reference check, screening and hiring test may be part of the procedure. If you join us, we ask you for a VOG (Certificate of Good Conduct).

Internal candidates will be given priority over external candidates in case of equal suitability.

Hallo. Wij zijn Amsterdam UMC. De krachten van AMC en VUmc gebundeld. Samen bouwen we aan een samenleving waarin patiënten worden genezen en ziekten worden voorkomen, vooral wanneer de aandoening bijzonder is en de behandeling complex. Deze bedrijfspagina is automatisch gegenereerd en bevat daarom nog weinig informatie. Je vindt meer informatie over ‘bedrijfsnaam’ op hun website: ‘’Carrierewebsite’’

Healthcare
Amsterdam
1,000 employees