PhD candidate in gene regulatory mechanisms underpinning cardiovascular diseases

Functie inhoud

We are seeking a motivated PhD student to join our lab at Erasmus University Medical Centre in Rotterdam, exploring the gene regulatory mechanisms underpinning cardiovascular diseases.

Type 2 diabetes and elevated blood lipid levels are major risk factors for cardiovascular disease. Genome-wide association studies (GWAS) have identified numerous genetic variants linked to such traits, but the biological mechanisms behind these associations remain unclear. We use population genomics, multi-omics datasets and single cell profiling to bridge the gap between genetic discoveries and clinical application.

The PhD project will focus on a data-driven approach to construct novel polygenic scores and gene regulatory networks using data from large cohorts and in-house experiments on patient-specific iPSC-derived pancreatic cells. The candidate will play a key role in shaping the project and contributing to innovative research, with the ultimate goal of advancing personalised treatments.

Werkomgeving

Our newly established lab is part of the department of internal medicine, the largest department of Erasmus University Medical Centre. Collaboration is at the heart of our research, working closely with clinicians, lab core facilities, and data-driven researchers in various departments. The vascular medicine research lab is a lively environment where students, PhD students, postdocs and analysts work together, always ready to assist each other with research questions and challenges.

Profiel

• Highly motivated candidate who thrives in a collaborative environment.
• Masters degree in (molecular) biology, biomedical sciences, biotechnology, statistics or related field.
• Excellent command of written and spoken English.
• Basic programming skills (R/Python) and motivation to become proficient.
• Experience in cell culture, gene editing, or single cell profiling is a plus.

Wat bieden wij

• You will receive a temporary position for 3,5 years.
• The gross monthly salary is € 3.017,- in the 1st year and increases to € 3.824 ,- in the 4th year (scale OIO).
• Excellent fringe benefits, such as a 13th month that is already paid out in November and a individual travel expense package. Pension insurance with ABP.
• We take care of approximately 2/3 of the monthly contribution.
• Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work.