Postdoctoral fellow to study the hematopoietic stem cell niche in leukemia

Job description

The Department of Hematology at the Erasmus Medical Center Cancer Institute runs an ambitious and internationally recognized research program in the field of bone marrow failure and leukemia. The overall goal of our laboratory is to gain a better understanding of the cellular elements and molecular pathways driving leukemogenesis. Specifically, we aim to understand the interplay between the bone marrow immune-microenvironment and hematopoietic stem/progenitor cells in this process.

The postdoctoral projects will focus on dissecting the role of inflammatory signaling in the stem cell niche in malignant transformation in the hematopoietic system. We will exploit mouse modeling and state-of-the art (single-cell) molecular tools and strive to translate insights to human disease, exploring therapeutic modalities aimed at targeting inflammatory niche signaling in the immune-microenvironment to treat and prevent leukemia.

Work environment

A healthy population and excellence in healthcare through research and education. This is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way. In research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.

The department of Hematology hosts a highly interactive group of researchers and physicians with a common goal to conduct basic and translational research in the field of molecular aspects of bone marrow malignancies and to improve patient health. It accommodates a state of the art infrastructure for cell biological, genomic and clinically applied research.

Qualifications and skills

The position should appeal to scientists who want to perform cutting edge basic/translational research applying in vitro and in vivo modeling with the ultimate goal to develop novel therapeutics. The following skills and qualifications are required:

• Demonstrated track record in basic/translational research (at least one publication with impact).
• Excellent oral and written communication skills in English.
• High level of motivation and ability to work in a team.
• Expertise in hematology, immunology and/or stem cell biology, bio-informatical analyses of single cell data and mouse modeling would be highly recommendable. Being able to present a certificate of good conduct is a condition for the appointment.

Terms of employment

• The gross monthly salary amounts a maximum of € 6.402,- (scale 11), depending on your level of educacation and relevant experience, based on a full-time working week of 36 hours.
• You will receive a contract for 1 year.
• Excellent fringe benefits, such as a 13th month that is already paid out in
• November and an individual travel expense package.
• Pension insurance with ABP, we take care of approximately 2/3 of the
• monthly contribution.
• Special benefits, such as an incompany physiotherapist and bicycle
• repairer. There is also a gym where you can work on your fitness after work.