PhD Position in Single-Molecule Biophysic

We are seeking a motivated PhD student to use single-molecule techniques and computational tools to explore molecular interactions and apply them for therapeutic applications.

Job description

We are looking for a PhD student passionate about understanding molecular mechanisms in biological systems. This position involves applying single-molecule techniques to study molecular interactions, including protein-ligand interactions and protein-peptide interactions. The candidate will work in an interdisciplinary environment, combining experimental approaches such as single molecule fluorescence and biochemistry with computational methods.

The candidate will obtain single-molecule multiplexing data and validate machine learning predictions using high-throughput data. The successful candidate will collaborate with international partners for therapeutic applications of this research. The project offers opportunities to make significant contributions to understanding molecular interactions and their implications for both fundamental and medical sciences.

Job requirements

• MSc degree (or nearing completion) in physics, biophysics, computational biology, or a related field.
• Strong programming skills (Python) and experience in data analysis and computational methods.
• Familiarity with molecular biology techniques.
• Excellent written and spoken English skills.
• Ability to work effectively in a collaborative, international, and interdisciplinary environment.

TU Delft (Delft University of Technology)

TU Delft is a top international university combining science, engineering and design. It delivers world class results in education, research and innovation to address challenges in the areas of energy, climate, mobility, health and digital society. At TU Delft, engineers are entrepreneurial problem-solvers in both business and social contexts.

Faculty Applied Sciences

With more than 1,100 employees, including 150 principal investigators, and about 3,600 students, the Faculty of Applied Sciences offers an inspiring scientific ecosystem. The faculty focuses on key enabling technologies such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion. Its scientists conduct fundamental and applied research in Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics.

Conditions of employment

Doctoral candidates will be offered a 4-year period of employment in principle, in the form of 2 employment contracts. An initial 1.5 year contract includes an official go/no go progress assessment within 15 months, followed by an additional contract for the remaining 2.5 years assuming performance requirements are met.

As a PhD candidate you will be enrolled in the TU Delft Graduate School. The TU Delft Graduate School provides an inspiring research environment with an excellent team of supervisors, academic staff and a mentor. The Doctoral Education Programme is aimed at developing your transferable, discipline-related and research skills.

TU Delft offers a customisable compensation package, discounts on health insurance, and a monthly work costs contribution. Flexible work schedules can be arranged.

Will you need to relocate to the Netherlands for this job? TU Delft is committed to making your move as smooth as possible. The HR unit, Coming to Delft Service, offers information and events to help you prepare your relocation, settle in the Netherlands, and expand your social network in Delft. A Dual Career Programme is available to support your accompanying partner with their job search in the Netherlands.

Additional information

#EUfunded This is an EU funded project, named MORPHEOS: neuroMORPHic fluidic circuits Enabled by artificial iOn channelS, within program Horizon Europe / Marie Skłodowska-Curie Actions Doctoral Networks.

Doing a PhD at TU Delft requires English proficiency at a certain level to ensure that the candidate is able to communicate and interact well, participate in English-taught Doctoral Education courses, and write scientific articles and a final thesis.

Please note:

• As part of knowledge security, TU Delft conducts a risk assessment during the recruitment of personnel to help prevent the unwanted transfer of sensitive knowledge and technology. The assessment is based on information provided by candidates, such as their motivation letter and CV, and takes place at the final stages of the selection process. When the outcome is negative, the candidate will be informed. The processing of personal data in this context is carried out on the legal basis of the GDPR: performing a public task in the public interest.