Magnet.me  -  Het slimme netwerk waarop hbo‑ en wo‑studenten hun baan of stage vinden.

Het slimme netwerk waarop hbo‑ en wo‑studenten hun baan of stage vinden.

Deze vacature is verlopen. Je kunt daarom niet meer liken of solliciteren.

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Postdoctoral Fellow - Complex Disease Genetics

Baan GB
Geplaatst 23 mrt. 2024
Werkervaring
0 tot 2 jaar
Full-time / part-time
Full-time
Functie
Soort opleiding
Taalvereiste
Engels (Vloeiend)

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Fixed Term Contract for 3 Years.

Applications are invited for a 3-year Postdoctoral Fellowship at the Wellcome Sanger Institute based jointly in the teams of Dr. Carl Anderson (Human Genetics Programme, www.andersonlab.info) and Dr. Maya Ghoussaini (Open Targets). This is an exciting opportunity for you to bring together cutting-edge genetic and genomic datasets to identify novel candidate therapeutic targets for inflammatory bowel disease (IBD). IBD is a chronic and debilitating disease of the gastrointestinal tract that affects 0.5% of the European population. The etiological basis is poorly understood and, as a result, existing therapeutics often fail, leaving patients to face life-changing surgical procedures.

Genome-wide association studies have identified 240 regions of the human genome associated with IBD susceptibility. As for the majority of complex disease GWAS hits, the causal variants at the majority of these loci are unknown but are believed to have their effect on disease by changing the expression of nearby genes. In order to extract causal biological insights from IBD GWAS discoveries, and identify potentially novel therapeutic targets, a vital next step is to identify these genetically dysregulated genes and discover which other phenotypes these are associated with.

During this fellowship, you will lead a collaborative project to build a causal evidence base for every gene within IBD associated GWAS loci. Your affiliation with the Ghoussaini Team will bring access to the massive cross-disease genetic and genomic datasets aggregated by Open Targets and presented in their web-based portals (www.targetvalidation.org and https://genetics.opentargets.org). As a member of the Anderson group, you will also have access to the latest large-scale genetic association data for IBD.

Open Targets (opentargets.org) is a public-private initiative between the EMBL-EBI, GlaxoSmithKline (GSK), Biogen, Celgene, Takeda, Sanofi and the Wellcome Sanger Institute (WSI). You will benefit from working closely with other scientists from Open Targets partner institutions with expertise in statistical genetics, inflammatory bowel disease and drug development. As such, this fellowship will suit a self-motivated individual with good communication skills who is looking to make a personal contribution to genomic research at the interface of academia and the pharmaceutical industry.

Essential Skills

  • Ability to work with others in a collegiate and collaborative environment.
  • Motivation and ambition to make a personal contribution to genomic research
  • A PhD in a relevant subject (genetics, functional genomics, computer science, maths)
  • Experience with large-scale computational analysis
  • Statistical/computational genetics skills and an analytical mindset
  • Experience with computer programming & scripting
  • An attention to detail and a drive for rigor
  • Previous experience with analysis of genotype, sequence or functional genomic data.

Ideal Skills

  • Strong scientific publication record
  • An interest in understanding the biological basis of immune-mediated diseases

The Wellcome Sanger Institute is a genome research centre set up in 1992 by the Wellcome Trust and the Medical Research Council in order to further our knowledge of genomes, and in particular to play a substantial role in the sequencing and interpretation of the human genome. This information will underpin research on human biology and disease in this century and beyond.

Chemie
Onbekend
750 medewerkers