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Postdoctoral Fellow in Synthetic Genomics

Job GB
Posted 23 Mar 2024
Work experience
0 to 2 years
Full-time / part-time
Full-time
Job function
Degree level
Required language
English (Fluent)

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Fixed Term Contract for 3 years

A postdoctoral position is available at the Wellcome Sanger Institute to advance research in human genome synthetic genomics. This position will be led by Tom Ellis and David Adams as part of the Institute’s new Synthetic Genomics Initiative working within the Institute’s Cancer section. The role will coordinate with ongoing research in cancer genomics, and new research in designing and implementing synthetic genomics methods for the human genome. This is an exciting opportunity for the successful candidate to develop and demonstrate state-of-the-art methods for using genome engineering and genomic loci synthesis to synthetically probe the effects of mutation and rearrangement on a major cancer gene. As the goal is focused on showcasing technology development, there will be substantial freedom for the postdoc to guide the research of the project.

The successful applicant will hold a PhD and will have gained significant experience and expertise in a range of molecular and cell biology techniques. Experience in the following is desired but not essential: genome editing, viral- or transposon-mediated DNA delivery, DNA assembly and manipulation, site-specific integration and microbial synthetic biology. Successful candidates will be expected to drive forward the project, working closely with relevant members of the Institute and the wider scientific community to accomplish scientific objectives.

Essential Skills

  • A PhD in a relevant area of Biological Sciences, and a passion for problem solving
  • Experience in a range of relevant molecular biology techniques
  • Experience of mammalian cell biology techniques
  • The ability to effectively communicate with collaborators and occasionally present oral communication to large groups
  • Proven independent working style, technical problem solving, data analysis and generation of novel ideas

Ideal Skills

  • Experience in mammalian cell culture and molecular biology
  • Experience in DNA manipulation technologies, especially approaches to deliver and site-specifically integrate large pieces of DNA into genomes
  • Experience in genome editing and engineering
  • Experience in yeast or E. coli synthetic biology

The Wellcome Sanger Institute is a genome research centre set up in 1992 by the Wellcome Trust and the Medical Research Council in order to further our knowledge of genomes, and in particular to play a substantial role in the sequencing and interpretation of the human genome. This information will underpin research on human biology and disease in this century and beyond.

Chemical
Unknown
750 employees