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Modeling Cellular Decision Making during Multicellular Development

Posted 23 Mar 2024
Work experience
0 to 7 years
Full-time / part-time
Full-time
Job function
Salary
€2,960 - €4,670 per month
Degree level
Required language
English (Fluent)

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Functie

The Ten Tusscher lab

externe link

currently offers a postdoctoral research position in Computational Developmental Biology. A fundamental question in biology is how precursor cells choose between and commit to specialized cellular fates, and how these fate decisions are coordinated with a permanent arrest of cell division. To address these questions, you will develop quantitative dynamic models of the regulatory logic underlying cell fate decisions in developing animal tissues. Aim of the project is to reveal the key players and architecture of the regulatory network they constitute, the signaling between cell types and across tissues, and to decipher how all of this together shapes cell fate decisions. The project is part of a larger NWO-Groot project. Developed models will be based on high quality, detailed time-resolved experimental data obtained through the latest technologies in transcriptome, epigenome, and proteome analysis as well as detailed tracking of cell divisions.The project will be carried out in close collaboration with specialists in C. elegans development (van den Heuvel lab, UU, Korswagen lab, Hubrecht Institute), single-cell analysis (Korswagen and van Oudenaarden labs, Hubrecht Institute), and proteomics techniques (Vermeulen lab, Radboud University Nijmegen).

You will become part of the highly interactive Computational Biology community at Utrecht University. You will interact daily with fellow Researchers in the Theoretical Biology and Bioinformatics group and meet regularly with our consortium partners at the Developmental Biology group, Hubrecht Institute and Radboud University.

Profiel

We are looking for a curious and dedicated candidate who has a strong interest in mathematical modeling and computational biology in the context of developmental biology and gene regulation. We would also like you to bring the following qualifications:

  • a PhD degree in Computational Biology, Applied Mathematics, Physics, Computer Science, or a related field;
  • experience in mathematical, differential equation based modeling and programming;
  • a strong interest in developmental biology and gene regulatory networks;
  • trained in scientific writing, communication and presentation in English;
  • motivated to work in a dynamic, multidisciplinary and international research team;
  • experience with bioinformatics and network inference from data will be considered a bonus.

Aanbod

  • A position for a year, that can be prolonged after a positive evaluation.
  • Embedding in and learning from a great team of top Computational Biologists and Life Sciences Researchers.
  • The chance to work with next-level integrated, single cell omics data for model development.
  • A full-time gross salary, depending on previous qualifications and experience, that ranges between €2,960 and €4,670 per month (scale 10) according to the Collective Labour Agreement Dutch Universities.
  • A 8% holiday bonus and 8.3% end-of-year bonus.
  • A pension scheme, partially paid parental leave, and flexible employment conditions externe link
  • based on the Collective Labour Agreement (CAO) Dutch Universities.

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Education
Utrecht
7,000 employees