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The Ten Tusscher lab
currently offers a postdoctoral research position in Computational Developmental Biology. A fundamental question in biology is how precursor cells choose between and commit to specialized cellular fates, and how these fate decisions are coordinated with a permanent arrest of cell division. To address these questions, you will develop quantitative dynamic models of the regulatory logic underlying cell fate decisions in developing animal tissues. Aim of the project is to reveal the key players and architecture of the regulatory network they constitute, the signaling between cell types and across tissues, and to decipher how all of this together shapes cell fate decisions. The project is part of a larger NWO-Groot project. Developed models will be based on high quality, detailed time-resolved experimental data obtained through the latest technologies in transcriptome, epigenome, and proteome analysis as well as detailed tracking of cell divisions.The project will be carried out in close collaboration with specialists in C. elegans development (van den Heuvel lab, UU, Korswagen lab, Hubrecht Institute), single-cell analysis (Korswagen and van Oudenaarden labs, Hubrecht Institute), and proteomics techniques (Vermeulen lab, Radboud University Nijmegen).
You will become part of the highly interactive Computational Biology community at Utrecht University. You will interact daily with fellow Researchers in the Theoretical Biology and Bioinformatics group and meet regularly with our consortium partners at the Developmental Biology group, Hubrecht Institute and Radboud University.
We are looking for a curious and dedicated candidate who has a strong interest in mathematical modeling and computational biology in the context of developmental biology and gene regulation. We would also like you to bring the following qualifications:
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