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PhD candidate, for the chemical synthesis of immune modulating molecules

Posted 26 Mar 2024
Work experience
1 to 3 years
Full-time / part-time
Full-time
Job function
Degree level
Required language
English (Fluent)

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The Faculty of Science and the Leiden Institute of Chemistry are looking for a

PhD candidate, for the chemical synthesis of immune modulating molecules

Key responsibilities

Precise modulation of the immune response is essential for the proper working of vaccines. Yet we understand little about the kinetics of these processes in real immune cells. Over the last few years, we have been applying chemical approaches that can help study this problem. Using bio-compatible protecting group chemistry (so-called click to release) we can now control the start of these processes in vivo. In this project we aim to synthesize new, complex immune modulating molecules with these protecting groups installed. For this we are looking for a skilled organic chemist, preferably one with experience in chemical biology approaches. One who wants to see his molecules used in biological experiments, and who has a willingness to learn from and interact with the biology-PhDs also working on this project.

Selection criteria

  • Master degree in organic chemistry, or equivalent;
  • Proven interest in total synthesis and/or proven interest in the synthetic aspects of chemical biology techniques;
  • Proficient in English;
  • Excellent communication skills.

Our organisation

The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to make a contribution to addressing the major societal challenges of the future.

The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organised in eight institutes. These institutes offer eight bachelor’s and twelve master’s programmes. The faculty has grown strongly in recent years and now has more than 2.200 staff and almost 4,200 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together.

The chemistry and life science research in the Leiden Institute of Chemistry (LIC) is organized around two major research areas: ‘Chemical Biology’ and ‘Energy & Sustainability’. The institute’s research themes illustrate the central position of chemistry between biology, medicine and physics. The various research topics carried out within these themes are ideal for executing interdisciplinary research. For more information, see the website of the Faculty of Science.

Terms and conditions

We offer a full-time position for initially one year. After a positive evaluation of the progress of the thesis, personal capabilities and compatibility the appointment will be extended by a further three years. Salary range from € 2.395,- to € 3.061,- gross per month (pay scale P in accordance with the Collective Labour Agreement for Dutch Universities).

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses(8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break. effectiveness.

Diversity

Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

De Universiteit Leiden is één van Europa’s meest vooraanstaande internationale onderzoeksuniversiteiten. De universiteit heeft zeven faculteiten in het alfa-, bèta- en gammadomein, is gevestigd in Leiden en Den Haag en heeft ruim 6.700 medewerkers en 29.520 studenten. Haar motto is Praesidium Libertatis – Bolwerk van Vrijheid.
Dankzij de bevlogen en betrokken medewerkers heeft de universiteit een leidende rol in wetenschappelijk onderzoek…


De Universiteit Leiden is één van Europa’s meest vooraanstaande internationale onderzoeksuniversiteiten. De universiteit heeft zeven faculteiten in het alfa-, bèta- en gammadomein, is gevestigd in Leiden en Den Haag en heeft ruim 6.700 medewerkers en 29.520 studenten. Haar motto is Praesidium Libertatis – Bolwerk van Vrijheid.
Dankzij de bevlogen en betrokken medewerkers heeft de universiteit een leidende rol in wetenschappelijk onderzoek en onderwijs en scoort Leiden elk jaar zeer goed in toonaangevende rankings. De lat ligt dan ook hoog. Ongeacht welk werk u aan onze universiteit doet, u wordt altijd aangemoedigd om uw horizon te verbreden, uw talenten te ontplooien en het maximale uit uzelf te halen.

Education
Leiden
6,700 employees