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Postdoctoral fellow on the hematopoietic stem cell niche in leukemia

Posted 23 Mar 2024
Work experience
2 to 5 years
Full-time / part-time
Full-time
Job function
Degree level
Required language
Dutch (Fluent)
Deadline
30 Mar 2020 21:59

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Job description

The Department of Hematology at the Erasmus Medical Center Cancer Institute runs an ambitious and internationally recognized research program in the field of stem cell biology, bone marrow failure and leukemogenesis. The overall goal of our laboratory is to gain a better understanding of the cellular elements and molecular pathways driving leukemogenesis. Specifically, we aim to understand the interplay between the bone marrow microenvironment and hematopoietic cells in physiology and disease.

The postdoctoral projects will focus on dissecting the role of signaling in the stem cell niche in development, regeneration and in malignant transformation in the hematopoietic system. We will exploit mouse modeling and state-of-the art molecular tools and strive to translate insights to human disease, exploring therapeutic modalities aimed at targeting niche signaling to drive regeneration and treat bone marrow disease.

Work environment

The Department of Hematology hosts a highly interactive group of researchers and physicians with a common goal to conduct basic and translational research in the field of molecular aspects of bone marrow malignancies and to improve patient health. It accommodates a state of the art infrastructure for cell biological, genomic and clinically applied research.

Qualifications and skills

The position should appeal to most scientists who want to perform cutting edge basic/translational research applying in vitro and in vivo modeling with the ultimate goal to develop novel therapeutics. Furthermore the following skills and qualifications are required:

  • Demonstrated track record in basic/translational research (at least one publication with impact),
  • Expertise in hematology or stem cell biology,
  • Profound hands-on experience in molecular biological assays and techniques (FACS, RNA/DNASeq, Crispr-Cas9),
  • Solid hands-on experience in (hematological) mouse models (including bone marrow transplantation),
  • Excellent oral and written communication skills in English,
  • Highly motivated and a team-player.

Before you apply please check our conditions for employment.

Terms of employment

The gross monthly salary amounts a minimum of € 2.826,- (scale 10) and a maximum of € 5.226,- (scale 11), depending on your level of education and relevant experience and based on a full-time working week of 36 hours. The terms of employment are in accordance with the Collective Bargaining Agreement for University Medical Centers (CAO UMC).

We are Erasmus MC. Our roots lie in Rotterdam, a city and port of international standing. We are the most innovative university medical center in the Netherlands and one of the world’s leading centers of scientific research.

Healthcare
Rotterdam
10,000 employees